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Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins.
- Source :
-
Science (New York, N.Y.) [Science] 1996 Oct 25; Vol. 274 (5287), pp. 624-7. - Publication Year :
- 1996
-
Abstract
- A cytosolic yeast karyopherin, Kap104p, was isolated and shown to function in the nuclear import of a specific class of proteins. The protein bound directly to repeat-containing nucleoporins and to a cytosolic pool of two nuclear messenger RNA (mRNA) binding proteins, Nab2p and Nab4p. Depletion of Kap104p resulted in a rapid shift of Nab2p from the nucleus to the cytoplasm without affecting the localization of other nuclear proteins tested. This finding suggests that the major function of Kap104p lies in returning mRNA binding proteins to the nucleus after mRNA export.
- Subjects :
- Amino Acid Sequence
Biological Transport
Carrier Proteins chemistry
Carrier Proteins isolation & purification
Cytosol chemistry
Cytosol metabolism
Membrane Proteins metabolism
Molecular Sequence Data
Mutation
Nuclear Envelope metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Recombinant Fusion Proteins metabolism
Temperature
beta Karyopherins
Carrier Proteins metabolism
Cell Nucleus metabolism
Fungal Proteins metabolism
Karyopherins
Nuclear Pore Complex Proteins
Nuclear Proteins metabolism
Nucleocytoplasmic Transport Proteins
RNA-Binding Proteins metabolism
Saccharomyces cerevisiae metabolism
Saccharomyces cerevisiae Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 274
- Issue :
- 5287
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 8849456
- Full Text :
- https://doi.org/10.1126/science.274.5287.624