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Transplantation of human fetal striatum into a rodent model of Huntington's disease ameliorates locomotor deficits.
- Source :
-
Neuroscience research [Neurosci Res] 1996 Mar; Vol. 24 (4), pp. 415-20. - Publication Year :
- 1996
-
Abstract
- Previous studies have demonstrated that syngeneic transplants of striatal tissue can ameliorate locomotor deficits in rodent models of Huntington's disease (HD). In the present study, we have examined whether human to rat xenografts of fetal striatal tissue can exert a similar recovery of function. Rodents with unilateral striatal lesions were transplanted with human striatal cells from a donor 14 weeks post-conception, and subsequently displayed a progressive decrease in rotational asymmetry in comparison to sham (saline) transplanted animals. Histological analysis revealed acetylcholinesterase (AChE)-positive fibers and NADPH-diaphorase (NADPH-d)-positive neurons within transplanted tissue. These results suggest that human fetal striatum at a gestational age of 14 weeks may potentially be useful as a source of donor tissue for transplantation in the treatment of HD.
- Subjects :
- Acetylcholinesterase analysis
Acetylcholinesterase metabolism
Animals
Antiparkinson Agents pharmacology
Apomorphine pharmacology
Coloring Agents
Disease Models, Animal
Histocytochemistry
Humans
Locomotion drug effects
Male
NADPH Dehydrogenase analysis
NADPH Dehydrogenase metabolism
Neostriatum embryology
Neostriatum enzymology
Phenothiazines
Rats
Rats, Sprague-Dawley
Rotation
Brain Tissue Transplantation
Fetal Tissue Transplantation
Huntington Disease surgery
Neostriatum transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0168-0102
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 8861112
- Full Text :
- https://doi.org/10.1016/0168-0102(95)01009-2