Back to Search Start Over

Kinetic of in vitro generation of some hemorphins: early release of LVV-hemorphin-7, precursor of VV-hemorphin-7.

Authors :
Dagouassat N
Garreau I
Zhao Q
Sannier F
Piot JM
Source :
Neuropeptides [Neuropeptides] 1996 Feb; Vol. 30 (1), pp. 1-5.
Publication Year :
1996

Abstract

Bovine globin has been hydrolysed by pepsin to different degrees of hydrolysis. Analysis of the hydrolysates, by reversed-phase high-performance liquid chromatography (RP-HPLC), shows the release of LVV- and VV-hemorphin-7. LVV-hemorphin-7 was the first generated, at a degree of hydrolysis (DH), as low as 4%. In contrast, VV-hemorphin-7 was produced later. Our study clearly shows that VV-hemorphin-7 is issued directly from LVV-hemorphin-7, since this later completely disappeared during hydrolysis. This work allows us to suggest a possible pathway for in vivo hemorphins appearance.

Details

Language :
English
ISSN :
0143-4179
Volume :
30
Issue :
1
Database :
MEDLINE
Journal :
Neuropeptides
Publication Type :
Academic Journal
Accession number :
8868292
Full Text :
https://doi.org/10.1016/s0143-4179(96)90047-5