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Big babies and infant leukemia: a role for insulin-like growth factor-1?

Authors :
Ross JA
Perentesis JP
Robison LL
Davies SM
Source :
Cancer causes & control : CCC [Cancer Causes Control] 1996 Sep; Vol. 7 (5), pp. 553-9.
Publication Year :
1996

Abstract

Several epidemiologic studies have demonstrated that high birthweight is associated with an increased risk of infant leukemia; however, the reason for this relationship is unclear. Biologic data demonstrate that birth weight is correlated positively with circulating levels of insulin-like growth factor-1 (IGF-1). IGF-1 is important in blood formation and regulation and has been shown to stimulate the growth of both myeloid and lymphoid cells in culture. Since infants who develop leukemia are likely to have had at least one transforming event occur in utero, we hypothesize that high levels of IGF-1 may both produce a larger baby and contribute to leukemogenesis.

Details

Language :
English
ISSN :
0957-5243
Volume :
7
Issue :
5
Database :
MEDLINE
Journal :
Cancer causes & control : CCC
Publication Type :
Academic Journal
Accession number :
8877054
Full Text :
https://doi.org/10.1007/BF00051889