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Increased risk of infection with human immunodeficiency virus type 1 among uncircumcised men presenting with genital ulcer disease in Kenya.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 1996 Sep; Vol. 23 (3), pp. 449-53. - Publication Year :
- 1996
-
Abstract
- The factors responsible for the explosive spread of human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa continue to be identified and debated. One of the most controversial factors has been male circumcision. This cross-sectional study was conducted to measure the association between circumcision status and infection with HIV-1 among men with genital ulcer disease. Eight hundred and ten men participated in the study, of whom 190 (23%) were HIV-1-positive. A logistic regression model adjusted for behavioral and historical showed that HIV-1 positivity was independently associated with being uncircumcised (adjusted odds ratio [OR], 4.8; 95% confidence interval [CI], 3.3-7.2) and with a history of urethral discharge (adjusted OR, 2.0; 95% CI, 1.4-2.8). This association could not be explained by measures of sexual exposure to HIV-1 among this population. Male circumcision should be considered as an intervention strategy for AIDS control.
- Subjects :
- Adolescent
Adult
Chancroid complications
Cross-Sectional Studies
Genital Diseases, Male microbiology
HIV Infections transmission
Haemophilus ducreyi isolation & purification
Humans
Kenya epidemiology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Risk Factors
Skin Ulcer microbiology
Circumcision, Male statistics & numerical data
Genital Diseases, Male complications
HIV Infections epidemiology
HIV-1
Skin Ulcer complications
Subjects
Details
- Language :
- English
- ISSN :
- 1058-4838
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 8879763
- Full Text :
- https://doi.org/10.1093/clinids/23.3.449