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Regression of AIDS-related Kaposi's sarcoma during therapy with thalidomide.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 1996 Sep; Vol. 23 (3), pp. 501-3; discussion 504-5. - Publication Year :
- 1996
-
Abstract
- A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of grauntocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in blood.
- Subjects :
- Adolescent
DNA, Viral blood
Female
Granulocyte Colony-Stimulating Factor therapeutic use
HIV Infections complications
HIV Infections congenital
Humans
Remission Induction
Sarcoma, Kaposi etiology
Sarcoma, Kaposi immunology
Viral Load
HIV Infections immunology
Herpesvirus 8, Human isolation & purification
Immunosuppressive Agents therapeutic use
Sarcoma, Kaposi drug therapy
Thalidomide therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1058-4838
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 8879772
- Full Text :
- https://doi.org/10.1093/clinids/23.3.501