Back to Search
Start Over
Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain.
- Source :
-
The American journal of physiology [Am J Physiol] 1996 Oct; Vol. 271 (4 Pt 2), pp. R1096-100. - Publication Year :
- 1996
-
Abstract
- Recently, glucagon-like peptide-1-(7-36) amide (GLP-1) and leptin have been implicated in the regulation of food intake. In the present study, we compared the effects of third ventricular administration (i3vt) of leptin (3.5 micrograms) and GLP-1 (10.0 micrograms) on short-term food intake and c-Fos-like immunoreactivity (c-FLI) in hypothalamic, limbic, and hindbrain areas in the rat. Relative to controls, infusion of leptin or GLP-1 (3 h before lights off) significantly reduced food intake over the first 2 h in the dark phase (53 and 63%, respectively). In different rats, infusion of leptin or GLP-1 elevated c-FLI in the paraventricular hypothalamus and central amygdala. Furthermore, leptin selectively elevated c-FLI in the dorsomedial hypothalamus, whereas GLP-1 selectively elevated c-FLI in the nucleus of the solitary tract, area postrema, lateral parabrachial nucleus, and arcuate hypothalamic nucleus. The fact that most of the c-FLI after leptin or GLP-1 administration was observed in separate regions within the central nervous system (CNS) suggests different roles for leptin and GLP-1 in the CNS regulation of food intake and body weight.
- Subjects :
- Animals
Brain metabolism
Eating drug effects
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Immunohistochemistry
Injections, Intraventricular
Leptin
Male
Rats
Rats, Inbred Strains
Tissue Distribution
Brain physiology
Peptide Fragments pharmacology
Proteins pharmacology
Proto-Oncogene Proteins c-fos metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 271
- Issue :
- 4 Pt 2
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 8898006
- Full Text :
- https://doi.org/10.1152/ajpregu.1996.271.4.R1096