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Increase of tuberculous infection in the organs of B cell-deficient mice.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1996 Nov; Vol. 106 (2), pp. 312-6. - Publication Year :
- 1996
-
Abstract
- Protective immunity against infection with Mycobacterium tuberculosis is imparted by T cells rather than antibodies, but B cells can play a role as antigen-presenting cells and in granuloma formation. We re-evaluated the role of B cells in the course of tuberculous infection in mu-chain knock-out (Ig-) mice. Surprisingly, the organs of M. tuberculosis-infected Ig- mice were found to have three- to eight-fold elevated counts of viable bacilli compared with normal littermates at 3-6 weeks post-infection. Splenic interferon-gamma responses to whole antigen were unimpaired, whilst proliferation to certain mycobacterial peptides was found to be diminished. However, bacille Calmette-Guérin (BCG) vaccination significantly reduced the infection in Ig- mice. The mechanisms by which B cells can influence primary tuberculous infection need further study.
- Subjects :
- Animals
BCG Vaccine administration & dosage
Colony Count, Microbial
Cytokines metabolism
Enzyme-Linked Immunosorbent Assay
Female
Genes, Immunoglobulin genetics
Immunoglobulin mu-Chains genetics
Immunologic Deficiency Syndromes genetics
Male
Mice
Mice, Knockout
Spleen metabolism
T-Lymphocytes immunology
Tuberculosis prevention & control
Vaccination
B-Lymphocytes physiology
Immunologic Deficiency Syndromes microbiology
Liver microbiology
Lung microbiology
Mycobacterium tuberculosis isolation & purification
Spleen microbiology
Tuberculosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 106
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8918578
- Full Text :
- https://doi.org/10.1046/j.1365-2249.1996.d01-845.x