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Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain.
- Source :
-
Cytogenetics and cell genetics [Cytogenet Cell Genet] 1996; Vol. 72 (2-3), pp. 208-11. - Publication Year :
- 1996
-
Abstract
- From a human fetal-brain cDNA library we isolated a novel cDNA clone encoding a protein containing a CAP-GLY domain that is highly conserved among several cytoskeleton-associated proteins. The CAP-GLY domain is thought to be essential for their association with microtubules. The cDNA, designated CKAPI (for cytoskeleton-associated protein I, glycine motif) contained an open reading frame of 579 nucleotides encoding 193 amino acids. Northern-blot analysis revealed expression of three transcripts, 1.0, 3.4, and 4.6 kb in size, in all tissues examined. The 1.0-kb transcript was significantly higher in brain and heart than in other tissues. This gene was mapped by FISH to chromosome bands 19q13.11-->q13.12.
Details
- Language :
- English
- ISSN :
- 0301-0171
- Volume :
- 72
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Cytogenetics and cell genetics
- Publication Type :
- Academic Journal
- Accession number :
- 8978778
- Full Text :
- https://doi.org/10.1159/000134191