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Drug sensitivity of human immunodeficiency virus type 1 isolates after ribavirin therapy.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1997 Jan; Vol. 175 (1), pp. 176-8. - Publication Year :
- 1997
-
Abstract
- The antiviral agent ribavirin is effective against several virally induced diseases, and there is evidence that it might prove useful against human immunodeficiency virus type 1 (HIV-1) infection. Thus, there is interest in studying the resistance level of HIV-1 isolates to ribavirin following drug therapy. Low-passage clinical strains of HIV-1 were isolated from 3 patients undergoing treatment with ribavirin for 5-9 months. No significant changes in drug sensitivity were seen for sequential virus samples obtained before, during, and after antiviral therapy. These observations suggest that the appearance of a resistant phenotype is not induced by treatment with ribavirin in HIV-1-infected persons.
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 175
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 8985215
- Full Text :
- https://doi.org/10.1093/infdis/175.1.176