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Cutaneous alternariosis: role of corticosteroid-induced cutaneous fragility.
- Source :
-
Dermatology (Basel, Switzerland) [Dermatology] 1996; Vol. 193 (4), pp. 342-4. - Publication Year :
- 1996
-
Abstract
- Alternaria is a very common and saprophytic fungus. Cutaneous infection is rare and about 71 cases have been described, mainly in Europe in immunocompromised hosts. We report a case of dermal alternariosis occurring in a woman treated with corticosteroids for dermatomyositis. The cutaneous lesion consisted of an erythematous and scaly plaque on the leg measuring 2 x 2 cm. Cutaneous biopsy showed hyphae and round inclusions stained with PAS and Gomori-Grocott within a polymorphous granuloma. Cultures of cutaneous biopsies grew Alternaria sp. HIV1 and HIV2 serology was negative. The patient was treated by local excision and corticosteroids were decreased. One-year follow-up showed no recurrence. Cutaneous alternariosis is an opportunistic infection. the disease has been described mainly in patients treated with systemic corticosteroids (39 cases out of the 71 reported cases) or local corticosteroids (3/71) and in patients suffering from Cushing's syndrome (7/71) but rarely in HIV-infected patients (3/71). Cutaneous fragility induced by hypercorticism is an important cofactor permitting direct inoculation from the environment.
- Subjects :
- Aged
Biopsy, Needle
Dermatomycoses immunology
Dermatomycoses therapy
Dermatomyositis diagnosis
Dermatomyositis physiopathology
Female
Follow-Up Studies
Glucocorticoids therapeutic use
Humans
Immunosuppression Therapy
Opportunistic Infections immunology
Opportunistic Infections therapy
Prednisolone therapeutic use
Skin pathology
Alternaria isolation & purification
Dermatomycoses diagnosis
Dermatomyositis drug therapy
Glucocorticoids adverse effects
Opportunistic Infections diagnosis
Prednisolone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1018-8665
- Volume :
- 193
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Dermatology (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 8993964
- Full Text :
- https://doi.org/10.1159/000246287