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Analysis of HLA-DR split-specificity matching in cadaver kidney transplantation: a report of the Collaborative Transplant Study.
- Source :
-
Transplantation [Transplantation] 1997 Jan 15; Vol. 63 (1), pp. 57-9. - Publication Year :
- 1997
-
Abstract
- The influence of mismatches for HLA-DR "split" specificities was investigated in more than 8000 cadaver kidney transplants. HLA-DR typing was performed using DNA methodology. Among first transplants, mismatches defined by HLA-DR split specificities did not have a deleterious influence. Among retransplants, however, graft survival was significantly decreased if a mismatch was defined, considering split specificities in patients with no mismatch according to the "broad" definition (P=0.04) and also in grafts with two split mismatches, which showed only one mismatch according to the broad definition (P=0.03). Moreover, consideration of further "subsplit" specificities resulted in clinically relevant mismatches only among retransplants. These data indicate that the recognition of HLA-DR split specificity mismatches is fundamentally different in primary and regraft recipients. The results imply that recipients and donors of kidney retransplants should be typed for HLA-DR split specificities and that these specificities should be considered for organ allocation.
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 63
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 9000661
- Full Text :
- https://doi.org/10.1097/00007890-199701150-00011