[Activity of basic arginine- and lysine-residue cleaving carboxypeptidase in rats of various ages].

Activities of basic carboxypeptidases (CP) in rat brain regions and peripheral tissues were determined on postnatal days 0-90. The highest phenylmethylsulfonyl fluoride-inhibited activity was detected immediately after birth; activity decreases on day 10 with subsequent increase on day 20 and decrease on day 90. The CPE activity was the lowest immediately after birth, increased on day 30, and decreased on day 90. The lysosomal CPB activity was highest at birth and on day 90 and was the lowest on day 20. The activity of CPN slowly increases till day 20 and then it decreases. The relationship between dynamics of basic CP activity in ontogenesis and functional role of these enzymes is discussed.