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Systemic autoimmunity in LG/J mice.
- Source :
-
Immunology letters [Immunol Lett] 1996 Nov; Vol. 53 (2-3), pp. 153-5. - Publication Year :
- 1996
-
Abstract
- Humoral and end-organ parameters of autoimmunity were investigated in LG/J mice, which have traditionally been considered normal, non-diseased animals. Surprisingly, LG/J mice were found to possess autoantibodies, including antinuclear antibodies and rheumatoid factor, and to develop renal disease, including glomerulonephritis, interstitial nephritis, and perivasculitis, but not hepatic or cutaneous disease. In contrast, age-matched, identically-housed control animals failed to develop autoantibodies or end-organ disease. These findings have complications for the genetic study of lupus erythematosus in the MRL murine model, which derives heavily from the LG/J background. Thus, the LG/J strain may provide a useful model in the analysis of autoimmunity.
- Subjects :
- Animals
Antibodies, Antinuclear isolation & purification
Autoantibodies isolation & purification
Autoimmunity genetics
Female
Glomerulonephritis diagnosis
Glomerulonephritis immunology
Kidney Diseases diagnosis
Kidney Diseases immunology
Lupus Erythematosus, Systemic genetics
Male
Mice
Mice, Inbred MRL lpr
Mice, Inbred Strains
Nephritis, Interstitial diagnosis
Nephritis, Interstitial immunology
Rheumatoid Factor isolation & purification
Vasculitis diagnosis
Vasculitis immunology
Autoimmune Diseases diagnosis
Autoimmunity immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 53
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 9024995
- Full Text :
- https://doi.org/10.1016/s0165-2478(96)02616-8