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Incidence of acute oligoanuric renal failure in dextran 40 treated patients with acute ischemic stroke stage III or IV.
- Source :
-
Renal failure [Ren Fail] 1997 Jan; Vol. 19 (1), pp. 69-75. - Publication Year :
- 1997
-
Abstract
- Two hundred eleven patients with acute ischemic stroke, stage III or IV, received daily intravenous infusion of 500-1000 mL low-molecular dextran (dextran 40) over a period of 4 days. In 10 cases (4.7%) acute renal failure, associated with dextran infusion, could be observed; oligoanuria occurred after a mean time of 4 (3-6) days. The incidence of dextran-induced acute renal failure was significantly higher in patients with a preexisting reduction of glomerular filtration rate below 30 mL/min/1.73 m2 (p < 0.005). Five of the patients (50%) with acute renal failure died within 4-12 days after the hemodilution therapy with dextran 40; this high lethality was due to nonrenal complications.
- Subjects :
- Acute Disease
Acute Kidney Injury physiopathology
Adult
Aged
Aged, 80 and over
Anticoagulants administration & dosage
Anticoagulants therapeutic use
Anuria physiopathology
Brain Ischemia complications
Brain Ischemia diagnostic imaging
Dextrans administration & dosage
Dextrans therapeutic use
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Incidence
Infusions, Intravenous
Male
Middle Aged
Radiography
Renal Replacement Therapy
Retrospective Studies
Acute Kidney Injury chemically induced
Anticoagulants adverse effects
Anuria chemically induced
Brain Ischemia drug therapy
Dextrans adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0886-022X
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Renal failure
- Publication Type :
- Academic Journal
- Accession number :
- 9044453
- Full Text :
- https://doi.org/10.3109/08860229709026261