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Spermine modulates calcium flux through the rat erythrocyte membrane.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 1997 Feb; Vol. 20 (2), pp. 153-7. - Publication Year :
- 1997
-
Abstract
- The uptake of 45Ca by inside-out erythrocyte membrane vesicles (IOV) was dose-dependently inhibited by spermine. A cationic substance, Mg2+, did not affect this inhibitory activity of spermine. Ca(2+)-ATPase activity, however, was not inhibited by spermine at a concentration that could inhibit the uptake of 45Ca by the IOV. The release of 45Ca from IOV was significantly accelerated by spermine. Spermine bound to the surface of the IOV and was removed by treatment with acetic acid. These results suggest that spermine stimulates the release of Ca2+ from the IOV (or uptake of Ca2+ by erythrocytes) via an effect on the outer surface of the IOV (or the inner surface of erythrocytes).
- Subjects :
- Animals
Binding Sites
Calcium-Transporting ATPases antagonists & inhibitors
Carbon Radioisotopes
Cell Membrane Permeability drug effects
Enzyme Inhibitors pharmacology
Erythrocyte Membrane metabolism
Ion Transport
Male
Rats
Rats, Wistar
Spermine metabolism
Calcium metabolism
Erythrocyte Membrane drug effects
Spermine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 9057977
- Full Text :
- https://doi.org/10.1248/bpb.20.153