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Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 1997 Feb; Vol. 5 (2), pp. 393-6. - Publication Year :
- 1997
-
Abstract
- Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.
- Subjects :
- Anti-Inflammatory Agents, Non-Steroidal chemistry
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Humans
Isoenzymes analysis
Isoenzymes drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Membrane Proteins
Prostaglandin-Endoperoxide Synthases analysis
Prostaglandin-Endoperoxide Synthases drug effects
Recombinant Proteins analysis
Recombinant Proteins antagonists & inhibitors
Cyclooxygenase Inhibitors chemistry
Lipoxygenase Inhibitors chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9061203
- Full Text :
- https://doi.org/10.1016/s0968-0896(96)00255-6