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Comparative effects of the chelators sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) and diethylenetriaminepentaacetic acid (DTPA) on acute uranium nephrotoxicity in rats.
- Source :
-
Toxicology [Toxicology] 1997 Mar 14; Vol. 118 (1), pp. 49-59. - Publication Year :
- 1997
-
Abstract
- Sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) and diethylenetriaminepentaacetic acid (DTPA) are two chelating agents that have been demonstrated to be effective in the treatment of experimental poisoning by a number of heavy metals. In this study, the effects of Tiron and DTPA on uranium-induced nephrotoxicity were evaluated in a rat model. A series of four Tiron or DTPA injections was administered intraperitoneally to adult male Sprague-Dawley rats immediately after a single subcutaneous injection of uranyl acetate dihydrate (5 mg/kg) and at 24, 48 and 72 h thereafter. Positive and negative control groups received 0.9% saline with or without uranyl acetate, respectively. Tiron effectiveness was assessed at 400, 800 and 1600 mg/kg, whereas DTPA was administered at 250, 500 and 1000 mg/kg. Although the urinary excretion of uranium was significantly enhanced by Tiron administration, significant amounts of uranium still remained in the kidney at the end of the treatment. However, the partial reduction of the renal uranium concentrations was in accordance with the amelioration noted in some urinary and serum indicators of uranium nephrotoxicity. Moreover, Tiron administration also reduced the severity of the uranium-induced histological alterations in the kidney. According to these results, Tiron offers only a modest encouragement with regard to its possible therapeutic potential to treat acute uranium-induced nephrotoxic effects. In turn, DTPA was less effective than Tiron in protecting against the nephrotoxicity of uranium in rats.
- Subjects :
- 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt administration & dosage
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt therapeutic use
Acetylglucosaminidase urine
Animals
Chelating Agents administration & dosage
Chelating Agents therapeutic use
Creatinine metabolism
Creatinine urine
Dose-Response Relationship, Drug
Male
Pentetic Acid administration & dosage
Pentetic Acid therapeutic use
Poisoning prevention & control
Proteinuria urine
Rats
Rats, Sprague-Dawley
Uranium administration & dosage
Uranium urine
Urea urine
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt pharmacology
Chelating Agents pharmacology
Kidney drug effects
Organometallic Compounds toxicity
Pentetic Acid pharmacology
Uranium toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0300-483X
- Volume :
- 118
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 9074653
- Full Text :
- https://doi.org/10.1016/s0300-483x(96)03589-5