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Oral absorption and metabolism of quercetin and sugar-conjugated derivatives in specific transport systems.
- Source :
-
Cancer letters [Cancer Lett] 1997 Mar 19; Vol. 114 (1-2), pp. 175-7. - Publication Year :
- 1997
-
Abstract
- The intestinal transport and metabolism of quercetin and various sugar-conjugates were quantified in in vitro and in vivo model systems. The nature of the sugar moiety at the C3 and C4' position had no significant effect on the rate of transport. At the 10 microM level, quercetin and glycosides with sugars at position 3 were determined to be glucose transport carrier inhibitors.
- Subjects :
- Absorption
Animals
Caco-2 Cells
Chromatography, High Pressure Liquid
Humans
In Vitro Techniques
Monosaccharide Transport Proteins antagonists & inhibitors
Rats
Swine
Time Factors
Glycosides metabolism
Jejunum metabolism
Monosaccharide Transport Proteins metabolism
Quercetin analogs & derivatives
Quercetin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3835
- Volume :
- 114
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 9103284
- Full Text :
- https://doi.org/10.1016/s0304-3835(97)04655-7