Decreased anterior cingulate gyrus metabolic rate in schizophrenia.

Objective: This study examined glucose metabolism in the anterior and posterior cingulate cortex in schizophrenia.
Method: Fifty unmedicated male schizophrenic patients and 24 normal men were studied with positron emission tomography.
Results: Compared with the normal men, the schizophrenic patients had lower relative metabolic rates in the anterior cingulate and higher rates in the posterior cingulate.
Conclusions: The findings suggest hypofunction in the anterior cingulate cortex in schizophrenia.