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Spasmolytic activity of aurapten analogs.

Authors :
Yamada Y
Okamoto M
Kikuzaki H
Nakatani N
Source :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 1997 Apr; Vol. 61 (4), pp. 740-2.
Publication Year :
1997

Abstract

Seven coumaric compounds analogous to aurapten were synthesized. Their spasmolytic activity against Ba2+, acetylcholine and histamine was evaluated to investigate their structure-activity relationship. The results of the bioassay demonstrated the important roles of the cis type of double bond at C-2' and the epoxide between c-6' and 7'.

Subjects

Subjects :
Acetylcholine antagonists & inhibitors
Barium antagonists & inhibitors
Coumarins chemistry
Histamine Antagonists pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Parasympatholytics chemistry
Structure-Activity Relationship
Coumarins pharmacology
Parasympatholytics pharmacology

Details

Language :
English
ISSN :
0916-8451
Volume :
61
Issue :
4
Database :
MEDLINE
Journal :
Bioscience, biotechnology, and biochemistry
Publication Type :
Academic Journal
Accession number :
9145535
Full Text :
https://doi.org/10.1271/bbb.61.740
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