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The immunophenotypic characterization of bovine lymphomas.
- Source :
-
Veterinary pathology [Vet Pathol] 1997 May; Vol. 34 (3), pp. 222-5. - Publication Year :
- 1997
-
Abstract
- A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the national cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, gamma-heavy chain+, and lambda-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
- Subjects :
- Animals
Cattle
Enzootic Bovine Leukosis classification
Female
Lymphoma, B-Cell classification
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse veterinary
Lymphoma, Non-Hodgkin classification
Prospective Studies
Enzootic Bovine Leukosis immunology
Enzootic Bovine Leukosis pathology
Immunophenotyping veterinary
Leukemia Virus, Bovine
Lymphoma, B-Cell pathology
Lymphoma, B-Cell veterinary
Lymphoma, Non-Hodgkin pathology
Lymphoma, Non-Hodgkin veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9858
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 9163878
- Full Text :
- https://doi.org/10.1177/030098589703400307