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Androgen receptor protein binding properties and tissue distribution of 2-selena-a-nor-5alpha-androstan-17beta-ol in the rat.
- Source :
-
Steroids [Steroids] 1977 Jul; Vol. 30 (1), pp. 15-23. - Publication Year :
- 1977
-
Abstract
- 2-selena-A-nor-5alpha-androstan-17beta-ol was studied in vitro and in vivo in the rat prostate gland. The data demonstrates the ability of this compound to selectively complex with the specific receptors of 5alpha-dihydrotestosterone (5alpha-DHT) in the cytosol and to be retained in the nuclei in an unaltered form. Studies with selenium-75 labeled material suggests that the uptake and localization is similar to endogenous 5alpha-dihydrotestosterone.
Details
- Language :
- English
- ISSN :
- 0039-128X
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Steroids
- Publication Type :
- Academic Journal
- Accession number :
- 919015
- Full Text :
- https://doi.org/10.1016/0039-128x(77)90132-5