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[Cytokeratin and vimentin expression in laryngeal squamous cell carcinoma].
- Source :
-
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale [Acta Otorhinolaryngol Ital] 1996 Oct; Vol. 16 (5), pp. 420-7. - Publication Year :
- 1996
-
Abstract
- The present study employed immunohistochemical methods to study the cytokeratin (ck) and vimentin expression in 40 cases of laryngeal squamous cell carcinoma. Specific monoclonal isoform antibodies and mixes of antibodies vs. a specific molecule were used in order to determine what cytokeratins were present as accurately as possible. In this sampling two ck patterns were identified based on whether the ck pair 8/18 was present or not. The ck 8/18 positive cases were further broken down into three sub-groups based on the expression of one of the following: the ck 4/13 pair, ck 1/10 pair or vimentin. A statistically significant relationship was found between these sub-groups, the site at which the neoplasm arose and the tendency toward regional metastases. Moreover, it was found that the presence of ck 13 in a squamous cell carcinoma is correlated with the less aggressive forms, as indicated in the literature.
- Subjects :
- Adult
Aged
Female
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Retrospective Studies
Carcinoma, Squamous Cell chemistry
Carcinoma, Squamous Cell pathology
Keratins analysis
Laryngeal Neoplasms chemistry
Laryngeal Neoplasms pathology
Larynx chemistry
Larynx pathology
Vimentin analysis
Subjects
Details
- Language :
- Italian
- ISSN :
- 0392-100X
- Volume :
- 16
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
- Publication Type :
- Academic Journal
- Accession number :
- 9199086