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[The evaluation of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) level in peripheral blood of patients with chronic lower respiratory tract infection].
- Source :
-
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 1997 May; Vol. 71 (5), pp. 430-6. - Publication Year :
- 1997
-
Abstract
- In the present study, we assessed the serum level of IL-6 and TNF-alpha by ELISA in patients with chronic lower respiratory tract infection. The serum levels of IL-6 and TNF-alpha of patients in acute exacerbation phase are higher than that of in stable phase. We also classified patients in acute exacerbation phase into two groups according to the microorganism of persistent infection. The serum level of IL-6 and TNF-alpha in the patients with persistent infection with Pseudomonas aeruginosa were higher than that with Haemophilus influenzae. Moreover, the serum level of IL-6 and TNF-alpha were found to be related with malnutrition which assessed by clinical indices such as the serum level of albumin and cholinesterase. The present result suggests that IL-6 and TNF-alpha may have relationship with not only inflammation in airway but also indices of nutrition in patients with chronic lower respiratory tract infection.
- Subjects :
- Acute-Phase Reaction
Aged
Biomarkers analysis
Chronic Disease
Female
Haemophilus Infections physiopathology
Haemophilus influenzae
Humans
Male
Middle Aged
Nutritional Status
Pseudomonas Infections physiopathology
Respiratory Tract Infections microbiology
Interleukin-6 blood
Respiratory Tract Infections blood
Tumor Necrosis Factor-alpha analysis
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0387-5911
- Volume :
- 71
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9209124
- Full Text :
- https://doi.org/10.11150/kansenshogakuzasshi1970.71.430