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[The evaluation of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) level in peripheral blood of patients with chronic lower respiratory tract infection].

Authors :
Tsujimoto M
Sawaki M
Sakamoto M
Mikasa K
Hamada K
Maeda K
Teramoto S
Mori K
Ueda K
Narita N
Kita E
Source :
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 1997 May; Vol. 71 (5), pp. 430-6.
Publication Year :
1997

Abstract

In the present study, we assessed the serum level of IL-6 and TNF-alpha by ELISA in patients with chronic lower respiratory tract infection. The serum levels of IL-6 and TNF-alpha of patients in acute exacerbation phase are higher than that of in stable phase. We also classified patients in acute exacerbation phase into two groups according to the microorganism of persistent infection. The serum level of IL-6 and TNF-alpha in the patients with persistent infection with Pseudomonas aeruginosa were higher than that with Haemophilus influenzae. Moreover, the serum level of IL-6 and TNF-alpha were found to be related with malnutrition which assessed by clinical indices such as the serum level of albumin and cholinesterase. The present result suggests that IL-6 and TNF-alpha may have relationship with not only inflammation in airway but also indices of nutrition in patients with chronic lower respiratory tract infection.

Details

Language :
Japanese
ISSN :
0387-5911
Volume :
71
Issue :
5
Database :
MEDLINE
Journal :
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Publication Type :
Academic Journal
Accession number :
9209124
Full Text :
https://doi.org/10.11150/kansenshogakuzasshi1970.71.430