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Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 1997 Jul 20; Vol. 13 (11), pp. 945-52. - Publication Year :
- 1997
-
Abstract
- Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA responses in BALB/c and C57BL/6 mice. To determine if vaginal, gastric, or rectal boosting would enhance the induction of vaginal anti-HIV IgA responses over those observed with intranasal immunization only, C57BL/6 mice were intranasally immunized with the hybrid HIV peptide T1SP10MN(A) and cholera toxin (days 0 and 14) and boosted via the vaginal, gastric, or rectal route (days 7 and 28). Four intranasal immunizations was superior to all other immunizations evaluated for the induction of plasma anti-peptide IgG, vaginal anti-peptide IgG and IgA, and peptide-specific delayed-type hypersensitivity. In addition, intranasal priming with gastric boosting was associated with greatly elevated total serum IgE concentrations whereas intranasal immunization only was associated with only a modest increase in total serum IgE. These results suggest that intranasal immunization is a viable route of immunization for the induction of systemic and mucosal anti-HIV immune responses.
- Subjects :
- AIDS Vaccines immunology
Administration, Intranasal
Amino Acid Sequence
Animals
Female
HIV immunology
HIV Envelope Protein gp120 immunology
Hypersensitivity, Delayed
Immunoglobulin E blood
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mucous Membrane immunology
Peptide Fragments immunology
Rectum
Stomach
Vagina immunology
AIDS Vaccines administration & dosage
HIV Antibodies biosynthesis
HIV Antibodies blood
Vaccination methods
Subjects
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 9223410
- Full Text :
- https://doi.org/10.1089/aid.1997.13.945