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Cellular changes in prostatic carcinoma after treatment with orchidectomy, estramustine phosphate and medroxyprogesterone acetate.
- Source :
-
Scandinavian journal of urology and nephrology [Scand J Urol Nephrol] 1997 Jun; Vol. 31 (3), pp. 255-8. - Publication Year :
- 1997
-
Abstract
- Thirty-three patients with prostatic carcinoma were treated with either estramustine phosphate, orchidectomy or high dose medroxyprogesterone acetate. Therapy response was evaluated by cytological examination of fine needle aspiration biopsies performed before and after 6 weeks treatment. At follow-up, 11 of 14 patients treated with estramustine phosphate had regressive and/or degenerative changes, in 2 patients there were no prostatic carcinoma cells in the smears and in one there was a marked reduction of the number of tumour cells. In 7 of 10 patients treated with orchidectomy there was a marked reduction of the percentage of malignant cells while smears from 3 patients were unchanged. In the 8 patients treated with high dose medroxyprogesterone acetate the cell patterns were unmodified compared with before treatment. We conclude that, in contrast to the lack of effect of treatment with medroxyprogesterone acetate, treatment with orchidectomy and especially estramustine phosphate caused morphologic cellular changes in prostatic carcinoma.
- Subjects :
- Aged
Aged, 80 and over
Biopsy, Needle
Cell Survival drug effects
Combined Modality Therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Humans
Male
Middle Aged
Prostate drug effects
Prostate pathology
Prostatic Neoplasms therapy
Antineoplastic Agents, Hormonal therapeutic use
Estramustine therapeutic use
Medroxyprogesterone Acetate therapeutic use
Orchiectomy
Prostatic Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-5599
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 9249888
- Full Text :
- https://doi.org/10.3109/00365599709070343