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[Cytochrome P-450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in chronic liver diseases].
- Source :
-
Voprosy meditsinskoi khimii [Vopr Med Khim] 1997 Jul-Aug; Vol. 43 (4), pp. 256-60. - Publication Year :
- 1997
-
Abstract
- Repression of cytochrom P-450-dependent hydroxylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione-dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
Details
- Language :
- Russian
- ISSN :
- 0042-8809
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Voprosy meditsinskoi khimii
- Publication Type :
- Academic Journal
- Accession number :
- 9312941