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[Syncopes during simultaneous use of terfenadine and itraconazole].
- Source :
-
Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 1997 May 10; Vol. 141 (19), pp. 950-3. - Publication Year :
- 1997
-
Abstract
- A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis. Nine days after starting these drugs, she had several episodes of syncope. The ECG showed a long QT interval and torsades de pointes. The drugs were withdrawn and the patient temporarily received an infusion of isoprenaline, after which the QT interval returned to normal and no further episodes of torsades de pointes occurred. No other causes than the two drugs were found to explain these episodes.
- Subjects :
- Adult
Cardiotonic Agents therapeutic use
Female
Humans
Isoproterenol therapeutic use
Long QT Syndrome chemically induced
Long QT Syndrome drug therapy
Mycoses drug therapy
Rhinitis, Allergic, Seasonal drug therapy
Anti-Allergic Agents adverse effects
Antifungal Agents adverse effects
Itraconazole adverse effects
Syncope chemically induced
Terfenadine adverse effects
Subjects
Details
- Language :
- Dutch; Flemish
- ISSN :
- 0028-2162
- Volume :
- 141
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Nederlands tijdschrift voor geneeskunde
- Publication Type :
- Academic Journal
- Accession number :
- 9340542