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The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells.
- Source :
-
European journal of immunology [Eur J Immunol] 1997 Sep; Vol. 27 (9), pp. 2417-25. - Publication Year :
- 1997
-
Abstract
- Dendritic cells, in contrast to B lymphocytes, must be able to efficiently internalize a diverse array of antigens for processing and loading onto major histocompatibility complex (MHC) class II molecules. Here we characterize the mannose receptor pathway in dendritic cells and show that mannose receptor-mediated uptake of antigens results in a approximately 100-fold more efficient presentation to T cells, as compared to antigens internalized via fluid phase. Immunocytochemistry as well as subcellular fractionation revealed the localization of the mannose receptor and MHC class II molecules in distinct subcellular compartments. The mannose receptor thus functions in rapid internalization and concentration of a variety of glycosylated antigens that become available for processing and presentation. This may contribute to the unique capacity of dendritic cells to generate primary T cell responses against infectious agents.
- Subjects :
- Cell Compartmentation
Glycoconjugates immunology
HLA-D Antigens metabolism
Humans
Immunohistochemistry
Mannose Receptor
Antigen-Presenting Cells physiology
Dendritic Cells immunology
Lectins, C-Type
Mannose-Binding Lectins
Receptors, Cell Surface physiology
Receptors, Immunologic physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 27
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 9341788
- Full Text :
- https://doi.org/10.1002/eji.1830270941