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Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C.

Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C.

Authors :
Gavier B
Martínez-González MA
Riezu-Boj JI
Lasarte JJ
Garcia N
Civeira MP
Prieto J
Source :
Gastroenterology [Gastroenterology] 1997 Nov; Vol. 113 (5), pp. 1647-53.
Publication Year :
1997

Abstract

Background & Aims: In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome.<br />Methods: One hundred eighty-one patients with chronic hepatitis C who had been treated with interferon alfa for 12 months (median follow-up, 49 months) were studied. Viremia and aminotransferase levels at the first and third months of therapy as well as 10 pretreatment variables were assessed as potential independent predictors of sustained response to treatment.<br />Results: Sustained response occurred in 51 patients (28%). At month 1 of treatment, viral persistence accurately predicted nonresponse (predictive value, 95.3; 95% confidence interval, 86.0-98.8; P < 0.0001). Independent predictors of sustained response were undetectable viremia at the first month of therapy (P < 0.001), undetectable viremia at the third month (P < 0.001), younger age (P = 0.006), nonsporadic infection (P = 0.012), and higher pretreatment aspartate aminotransferase levels (P = 0.032). In patients who cleared HCV RNA at month 1 of therapy, the predicted probability of sustained response averaged 70% for those younger than 30 years and diminished by 10% for each decade of age.<br />Conclusions: Failure to clear HCV RNA at month 1 of treatment is strongly and independently associated with a very low probability of a sustained response to interferon.

Details

Language :
English
ISSN :
0016-5085
Volume :
113
Issue :
5
Database :
MEDLINE
Journal :
Gastroenterology
Publication Type :
Academic Journal
Accession number :
9352868
Full Text :
https://doi.org/10.1053/gast.1997.v113.pm9352868