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The effect of azelastine on the infiltration of inflammatory cells into the bronchial mucosa and clinical changes in patients with bronchial asthma.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 1997 Nov; Vol. 114 (3), pp. 285-92. - Publication Year :
- 1997
-
Abstract
- Background: Azelastine is an oral antiallergic compound but there is no direct evidence of its anti-inflammatory actions in bronchial asthma. We examined the effect of azelastine on inflammatory cells infiltrating the bronchial mucosa and clinical symptoms in atopic asthma in a double-blind, parallel, randomized study.<br />Methods: The study was completed by 13 subjects in the azelastine (4 mg/day) group and 11 subjects in the placebo group. Treatments were randomly administered for 3 months. Each subject recorded daily asthma symptoms and peak expiratory flow (PEF). Lung function and bronchial responsiveness to methacholine were measured before and after treatment. Fiberoptic bronchoscopy was performed and bronchial biopsies taken from segmental carinae before and after treatment with azelastine or placebo. Using each monoclonal antibody for eosinophils, mast cells, macrophages, and T lymphocytes we performed immunohistological staining on biopsy specimens.<br />Results: Compared with the placebo-treated group, the azelastine-treated group exhibited significant improvement of asthma symptoms (p<0.01), PEF (p<0.01), PEF diurnal variation (p<0.001), excluding forced expiratory volume in 1 s or airway responsiveness. This was accompanied by a reduction of EG2(+) eosinophils (p<0.01), CD3(+) (p<0.001), CD4(+) (p<0.05), CD8(+) (p<0.05) T lymphocytes, and CD25(+)-activated T lymphocytes (p<0.001) in the bronchial mucosa. Significant correlations were found between clinical data and immunohistochemical parameters.<br />Conclusion: These results demonstrated that the beneficial effects ofazelastine in bronchial asthma may result from modulation of local bronchial inflammatory cell infiltration.
- Subjects :
- Adolescent
Adult
Antigens, CD analysis
Asthma drug therapy
Bronchial Provocation Tests
Bronchodilator Agents administration & dosage
Double-Blind Method
Eosinophils immunology
Female
Humans
Immunity, Mucosal
Immunohistochemistry
Macrophages immunology
Male
Mast Cells immunology
Methacholine Chloride
Middle Aged
Mucous Membrane immunology
Peak Expiratory Flow Rate
Phthalazines administration & dosage
T-Lymphocytes immunology
Asthma immunology
Bronchi immunology
Bronchodilator Agents therapeutic use
Leukocytes immunology
Phthalazines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1018-2438
- Volume :
- 114
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 9363911
- Full Text :
- https://doi.org/10.1159/000237681