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Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1997 Nov 07; Vol. 40 (23), pp. 3707-11. - Publication Year :
- 1997
- Subjects :
- Animals
Anti-HIV Agents pharmacokinetics
Chemical Phenomena
Chemistry, Physical
HIV Protease Inhibitors pharmacokinetics
HIV-1 drug effects
Kinetics
Mice
Pyrones pharmacokinetics
Structure-Activity Relationship
Anti-HIV Agents chemical synthesis
Anti-HIV Agents pharmacology
HIV Protease Inhibitors chemical synthesis
HIV Protease Inhibitors pharmacology
HIV-1 enzymology
Pyrones chemical synthesis
Pyrones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 40
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9371233
- Full Text :
- https://doi.org/10.1021/jm970522y