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Recent and remote memory dissociation: medication effects and hippocampal function in schizophrenia.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1997 Oct 01; Vol. 42 (7), pp. 585-95. - Publication Year :
- 1997
-
Abstract
- Neuropsychological measures of recent and remote memory as well as general attention were administered to two groups of DSM-III-R schizophrenic patients in a within-subject repeated measures design across a 3-week interval. One group of patients (n = 12) was maintained on haloperidol for both test sessions, whereas a second group (n = 9) was tested first on haloperidol and again 3-weeks drug free. Patients received no adjunctive anticholinergic medication during the study. No differences were observed between the patient groups in level of psychotic symptomatology or general attention across the two test sessions. Patients withdrawn from haloperidol showed significant decreases in recent verbal memory function, while at the same time demonstrating significant increases in remote verbal memory. We speculate that the observed pattern of results is consistent with medial temporal lobe dysfunction particularly prominent in the left hemisphere as patients become drug free, and provides support for the existence of state-dependent cognitive changes in schizophrenia.
- Subjects :
- Adult
Antipsychotic Agents adverse effects
Attention drug effects
Double-Blind Method
Haloperidol adverse effects
Hippocampus drug effects
Humans
Male
Memory drug effects
Memory Disorders psychology
Memory, Short-Term drug effects
Neuropsychological Tests
Psychiatric Status Rating Scales
Antipsychotic Agents therapeutic use
Haloperidol therapeutic use
Hippocampus physiopathology
Memory Disorders etiology
Schizophrenia drug therapy
Schizophrenia physiopathology
Schizophrenic Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 9376455
- Full Text :
- https://doi.org/10.1016/S0006-3223(96)00435-0