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A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.
- Source :
-
The Journal of experimental medicine [J Exp Med] 1997 Dec 01; Vol. 186 (11), pp. 1809-18. - Publication Year :
- 1997
-
Abstract
- Natural killer (NK) cell-mediated lysis is negatively regulated by killer cell inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules. In this study, we characterize a novel inhibitory MHC class I receptor of the immunoglobulin-superfamily, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells. This receptor, called Ig-like transcript (ILT)2, binds MHC class I molecules and delivers a negative signal that inhibits killing by NK and T cells, as well as Ca2+ mobilization in B cells and myelomonocytic cells triggered through the B cell antigen receptor and human histocompatibility leukocyte antigens (HLA)-DR, respectively. In addition, myelomonocytic cells express receptors homologous to ILT2, which are characterized by extensive polymorphism and might recognize distinct HLA class I molecules. These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response.
- Subjects :
- Amino Acid Sequence
Antibodies, Monoclonal immunology
Calcium metabolism
Cell Line, Transformed
Cytotoxicity, Immunologic
Dendritic Cells immunology
Dendritic Cells metabolism
HLA-DR Antigens immunology
Humans
Intracellular Signaling Peptides and Proteins
Killer Cells, Natural immunology
Killer Cells, Natural metabolism
Leukemia, Basophilic, Acute pathology
Leukocyte Immunoglobulin-like Receptor B1
Leukocytes immunology
Lymphocyte Activation
Lymphocyte Subsets immunology
Lymphocyte Subsets metabolism
Macrophages immunology
Macrophages metabolism
Molecular Sequence Data
Monocytes immunology
Monocytes metabolism
Organ Specificity
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases metabolism
Receptors, Immunologic immunology
Sequence Alignment
Sequence Homology, Amino Acid
Serotonin metabolism
Superantigens immunology
Tumor Cells, Cultured
Antigens, CD
HLA Antigens metabolism
Leukocytes metabolism
Receptors, Immunologic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 186
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 9382880
- Full Text :
- https://doi.org/10.1084/jem.186.11.1809