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Campylobacter jejuni isolates from Japanese patients with Guillain-Barré syndrome.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1997 Dec; Vol. 176 Suppl 2, pp. S129-34. - Publication Year :
- 1997
-
Abstract
- Serologic evidence of recent Campylobacter jejuni infection was found in 92 (45%) of 205 Japanese patients with Guillain-Barré syndrome (GBS), and 49% of those 92 patients also had antibodies to GM1. Sixteen independent clinical isolates from GBS patients were serotyped: 12 belonged to Penner's heat-stable (HS) O serotype HS-19, 3 to HS-2, and 1 to HS-4. Of the patients whose C. jejuni isolates belonged to HS-19, 80% had elevated anti-GM1 antibodies. Although the correlation was significant between C. jejuni and GM1 antibody, anti-GM1 also was detected in 25% of patients without C. jejuni infection. Polymerase chain reaction-based restriction fragment length polymorphism analysis of an flaA gene showed that all HS-19 isolates, regardless of a GBS association, had an identical and distinguishable pattern, Cj-1, suggesting that HS-19:Cj-1 isolates are distinctive among C. jejuni isolates. Lectin typing showed that all GBS-associated HS-19 isolates contained terminal beta-N-acetylglucosamine residues on their cell surface, but HS-19 isolates from patients with enteritis did not.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Bacterial blood
Autoantibodies blood
Bacterial Typing Techniques
Campylobacter Infections complications
Campylobacter Infections epidemiology
Campylobacter jejuni classification
Campylobacter jejuni immunology
Child
Child, Preschool
DNA, Bacterial analysis
Female
Flagellin genetics
G(M1) Ganglioside immunology
Glycolipids immunology
Humans
Japan epidemiology
Lectins analysis
Male
Middle Aged
O Antigens analysis
O Antigens immunology
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polyradiculoneuropathy epidemiology
Polyradiculoneuropathy etiology
Seroepidemiologic Studies
Campylobacter Infections microbiology
Campylobacter jejuni isolation & purification
Polyradiculoneuropathy microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 176 Suppl 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9396696
- Full Text :
- https://doi.org/10.1086/513798