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Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
- Source :
-
Science (New York, N.Y.) [Science] 1998 Jan 30; Vol. 279 (5351), pp. 703-7. - Publication Year :
- 1998
-
Abstract
- Different classes of mammalian transcription factors-nuclear receptors, cyclic adenosine 3',5'-monophosphate-regulated enhancer binding protein (CREB), and signal transducer and activator of transcription-1 (STAT-1)-functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties. Retinoic acid receptor, CREB, and STAT-1 also require different histone acetyltransferase (HAT) activities to activate transcription. Thus, transcription factor-specific differences in configuration and content of the coactivator complex dictate requirements for specific acetyltransferase activities, providing an explanation, at least in part, for the presence of multiple HAT components of the complex.
- Subjects :
- Acetyltransferases genetics
CREB-Binding Protein
Cell Cycle Proteins genetics
Cyclic AMP metabolism
Cyclic AMP Response Element-Binding Protein metabolism
DNA-Binding Proteins metabolism
Gene Expression Regulation
HeLa Cells
Histone Acetyltransferases
Humans
Ligands
Mutation
Nuclear Receptor Co-Repressor 1
Nuclear Receptor Coactivator 1
Nuclear Receptor Coactivator 3
Promoter Regions, Genetic
Receptors, Retinoic Acid metabolism
Repressor Proteins metabolism
STAT1 Transcription Factor
Trans-Activators metabolism
Transcription Factors genetics
Transcriptional Activation
p300-CBP Transcription Factors
Acetyltransferases metabolism
Cell Cycle Proteins metabolism
Nuclear Proteins metabolism
Saccharomyces cerevisiae Proteins
Transcription Factors metabolism
Transcription, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 279
- Issue :
- 5351
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 9445475
- Full Text :
- https://doi.org/10.1126/science.279.5351.703