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Transcription factor-specific requirements for coactivators and their acetyltransferase functions.

Authors :
Korzus E
Torchia J
Rose DW
Xu L
Kurokawa R
McInerney EM
Mullen TM
Glass CK
Rosenfeld MG
Source :
Science (New York, N.Y.) [Science] 1998 Jan 30; Vol. 279 (5351), pp. 703-7.
Publication Year :
1998

Abstract

Different classes of mammalian transcription factors-nuclear receptors, cyclic adenosine 3',5'-monophosphate-regulated enhancer binding protein (CREB), and signal transducer and activator of transcription-1 (STAT-1)-functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties. Retinoic acid receptor, CREB, and STAT-1 also require different histone acetyltransferase (HAT) activities to activate transcription. Thus, transcription factor-specific differences in configuration and content of the coactivator complex dictate requirements for specific acetyltransferase activities, providing an explanation, at least in part, for the presence of multiple HAT components of the complex.

Details

Language :
English
ISSN :
0036-8075
Volume :
279
Issue :
5351
Database :
MEDLINE
Journal :
Science (New York, N.Y.)
Publication Type :
Academic Journal
Accession number :
9445475
Full Text :
https://doi.org/10.1126/science.279.5351.703