Back to Search
Start Over
Development of a therapeutic vaccine for the treatment of cocaine addiction.
- Source :
-
Drug and alcohol dependence [Drug Alcohol Depend] 1997 Dec 15; Vol. 48 (3), pp. 153-8. - Publication Year :
- 1997
-
Abstract
- No pharmacotherapies have yet been approved for the treatment of cocaine addiction. One new approach is to block the effects of cocaine with anti-cocaine antibodies induced by a therapeutic cocaine vaccine. A cocaine vaccine has been developed which induces a cocaine-specific antibody response in rodents. The antibody binds to cocaine in the circulation and can be shown to inhibit the ability of cocaine to enter the brain. Furthermore, anti-cocaine antibody can inhibit cocaine self-administration in rats. These data suggest that a cocaine vaccine may be a powerful therapeutic tool. The intent is to immunized motivated patients with the vaccine as part of a comprehensive treatment program. If the patient uses cocaine after being vaccinated, the antibody will inhibit the reinforcing activity of cocaine and decrease the likelihood of relapse.
- Subjects :
- Animals
Antigen-Antibody Complex pharmacology
Behavior, Addictive drug therapy
Blood-Brain Barrier
Brain Chemistry
Carrier Proteins pharmacology
Cocaine administration & dosage
Cocaine blood
Cocaine pharmacokinetics
Cocaine-Related Disorders immunology
Humans
Immunization, Passive
Mice
Rats
Self Medication
Serum Albumin, Bovine pharmacology
Cocaine immunology
Cocaine-Related Disorders drug therapy
Disease Models, Animal
Vaccines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0376-8716
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Drug and alcohol dependence
- Publication Type :
- Academic Journal
- Accession number :
- 9449013
- Full Text :
- https://doi.org/10.1016/s0376-8716(97)00121-x