The use of genetically resistant sheep to control nematode parasitism.

Research in the last 20 years has firmly established that it is possible to exploit genetic variation in resistance to the nematode parasites of sheep by selection. Selected sheep are more resistant to infection and commercial application of this research is under way in both Australia and in New Zealand. Not all the consequences of these breeding programs have been established, particularly long-term consequences for productivity and the interaction with other control measures, but the technology is available in the public domain with no commercial restrictions. Faecal worm egg count remains the most effective way of selecting sheep although many alternatives, such as DNA markers, host antibody and parasite antigen assays are being developed for use as selection criteria. Strategic nutritional supplementation is an immediate candidate for inclusion in worm control programs and although nematode vaccines remain elusive, it is likely that some will be field-tested in the next few years. For both of these approaches, nutritional and immunological, it is critical that the response of selected genotypes are assessed under commercial conditions and as components of worm control programs. There is evidence to support the possibility that selected sheep will be more responsive to vaccination while the long-term interaction between the effect of strategic nutritional supplements and resistant genotypes needs to be investigated.