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Structure and function of a sea urchin orthodenticle-related gene (HpOtx).
- Source :
-
Developmental biology [Dev Biol] 1998 Jan 15; Vol. 193 (2), pp. 139-45. - Publication Year :
- 1998
-
Abstract
- Two distinct types of orthodenticle-related proteins (HpOtxE/L) have been implicated as transcription activators of the aboral ectoderm-specific arylsulfatase (Ars) gene. Here, we describe the structure of HpOtx gene and present evidence that mRNAs of HpOtxE/L are transcribed from a single HpOtx gene by altering the transcription start site and by alternative splicing. By transactivation experiments, we have also demonstrated that HpOtxL activates the Ars promoter in the gastrula-stage embryo.<br /> (Copyright 1998 Academic Press.)
- Subjects :
- Animals
Arylsulfatases genetics
Base Sequence
Codon, Initiator
Drosophila Proteins
Enzyme Activation genetics
Gene Expression Regulation
Homeodomain Proteins chemistry
Luciferases genetics
Luciferases metabolism
Molecular Sequence Data
Promoter Regions, Genetic
Protein Structure, Tertiary
Recombinant Fusion Proteins physiology
Sequence Analysis, DNA
Transcription, Genetic
Genes, Homeobox
Homeodomain Proteins genetics
Homeodomain Proteins physiology
Sea Urchins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0012-1606
- Volume :
- 193
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 9473319
- Full Text :
- https://doi.org/10.1006/dbio.1997.8802