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[Interaction of L-glutamic acid with human T-lymphocytes].
- Source :
-
Bioorganicheskaia khimiia [Bioorg Khim] 1997 Oct; Vol. 23 (10), pp. 805-8. - Publication Year :
- 1997
-
Abstract
- A specific interaction of [3H]Glu with T lymphocytes from the blood of healthy donors (Kd = 0.236 microM) was revealed and described. It was found that unlabeled quisqualate, a structural analogue of L-glutamic acid, and unlabeled dipeptides Ala-Glu, Glu-Ala, and Glu-Glu competitively inhibit the specific binding of [3H]Glu to T lymphocytes (with Ki 0.19, 2.4, 3.4, and 1.2 microM, respectively). Binding experiments with conjugates of labeled and unlabeled glutamic acid with dextran showed that the receptors of [3H]Glu are localized on the outer surface of the plasma membrane of T lymphocytes.
- Subjects :
- Binding, Competitive drug effects
Cell Membrane metabolism
Dipeptides pharmacology
Glutamic Acid blood
Humans
Stereoisomerism
T-Lymphocytes drug effects
Excitatory Amino Acid Agonists pharmacology
Glutamic Acid metabolism
Quisqualic Acid pharmacology
Receptors, Glutamate metabolism
T-Lymphocytes metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0132-3423
- Volume :
- 23
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioorganicheskaia khimiia
- Publication Type :
- Academic Journal
- Accession number :
- 9490616