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Ultraviolet B irradiation modulates the immune system of fish (Rutilus rutilus, Cyprinidae). I. Phagocytes.
- Source :
-
Photochemistry and photobiology [Photochem Photobiol] 1998 Apr; Vol. 67 (4), pp. 433-7. - Publication Year :
- 1998
-
Abstract
- Roach (Rutilus rutilus) were irradiated with a single dose of ultraviolet B (UVB) radiation (0.4 J/cm2) in order to study the effects of UVB on the nonspecific immune defense mechanisms of fish. Neutrophils and macrophages were isolated from the head kidney of fish on days 1-14 postirradiation. Both random and directed migration of neutrophils, studied by migration under agarose assay, were suppressed on day 1 after UVB irradiation. The respiratory burst of phorbol 12-myristate 13-acetate-stimulated neutrophils and macrophages was also suppressed at days 1 and 2 after UVB irradiation. The suppression of migration and respiratory burst were restored or the responses were even enhanced later, but on the other hand spontaneous cytotoxicity of neutrophils toward 51chromium-labeled K562 target cells stayed suppressed throughout the 14 day follow-up. This study indicates that UVB radiation has the potential to suppress the functioning of phagocytes and to compromise the immune system of fish.
- Subjects :
- Animals
Carps immunology
Lymphoid Tissue radiation effects
Macrophages immunology
Macrophages radiation effects
Neutrophils physiology
Phagocytes drug effects
Phagocytes immunology
Respiratory Burst drug effects
Respiratory Burst radiation effects
Tetradecanoylphorbol Acetate pharmacology
Chemotaxis, Leukocyte radiation effects
Fishes immunology
Neutrophils radiation effects
Phagocytes radiation effects
Ultraviolet Rays
Subjects
Details
- Language :
- English
- ISSN :
- 0031-8655
- Volume :
- 67
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Photochemistry and photobiology
- Publication Type :
- Academic Journal
- Accession number :
- 9559587