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Differences in plasma concentrations of the D- and L-threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder.
- Source :
-
Psychiatry research [Psychiatry Res] 1998 Mar 20; Vol. 78 (1-2), pp. 115-8. - Publication Year :
- 1998
-
Abstract
- Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the D- and L-threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both D- and L-threo MPH enantiomers.
- Subjects :
- Analysis of Variance
Attention drug effects
Attention physiology
Attention Deficit Disorder with Hyperactivity classification
Attention Deficit Disorder with Hyperactivity drug therapy
Attention Deficit Disorder with Hyperactivity physiopathology
Central Nervous System Stimulants chemistry
Central Nervous System Stimulants pharmacokinetics
Child
Drug Resistance
Event-Related Potentials, P300 drug effects
Event-Related Potentials, P300 physiology
Female
Humans
Isomerism
Male
Methylphenidate chemistry
Methylphenidate pharmacokinetics
Volition drug effects
Volition physiology
Attention Deficit Disorder with Hyperactivity blood
Central Nervous System Stimulants blood
Methylphenidate blood
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 78
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 9579707
- Full Text :
- https://doi.org/10.1016/s0165-1781(97)00138-8