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Intracellular calcium signaling systems in the pathophysiology of affective disorders.
- Source :
-
Life sciences [Life Sci] 1998; Vol. 62 (17-18), pp. 1665-70. - Publication Year :
- 1998
-
Abstract
- In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.
- Subjects :
- Affective Disorders, Psychotic drug therapy
Affective Disorders, Psychotic metabolism
Animals
Antidepressive Agents pharmacology
Antidepressive Agents, Tricyclic pharmacology
Calcium blood
Calcium metabolism
Clomipramine pharmacology
Humans
Rats
Serotonin pharmacology
Selective Serotonin Reuptake Inhibitors pharmacology
Affective Disorders, Psychotic physiopathology
Calcium physiology
Signal Transduction physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 62
- Issue :
- 17-18
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 9585154
- Full Text :
- https://doi.org/10.1016/s0024-3205(98)00125-8