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Effects of beta-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans.
Effects of beta-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans.
- Source :
-
European journal of applied physiology and occupational physiology [Eur J Appl Physiol Occup Physiol] 1998 May; Vol. 77 (6), pp. 523-6. - Publication Year :
- 1998
-
Abstract
- We investigated the mechanisms of stress-induced alterations in adrenocorticotrophin (ACTH) release. Tandem parachutists received either a placebo or the beta-adrenoceptor antagonist propranolol prior to a first time parachute jump. Blood samples were drawn 4 h before, immediately after, and 1 h after the jump. Cortisol and catecholamine concentrations displayed a significant stress-induced increase in both groups. The ACTH plasma concentrations significantly increased in the placebo and the propranolol group, with significantly more pronounced changes in the propranolol-treated subjects compared to the placebo group. These data demonstrated a stress-induced increase of ACTH plasma concentrations in humans that was enhanced by beta-blockade.
- Subjects :
- Adrenocorticotropic Hormone blood
Adult
Double-Blind Method
Epinephrine blood
Humans
Hydrocortisone blood
Male
Norepinephrine blood
Stress, Psychological blood
Adrenergic beta-Antagonists pharmacology
Adrenocorticotropic Hormone metabolism
Propranolol pharmacology
Stress, Psychological physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0301-5548
- Volume :
- 77
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of applied physiology and occupational physiology
- Publication Type :
- Academic Journal
- Accession number :
- 9650737
- Full Text :
- https://doi.org/10.1007/s004210050370