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Effects of beta-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans.

Effects of beta-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans.

Authors :
Oberbeck R
Schürmeyer Th
Jacobs R
Benschop RJ
Sommer B
Schmidt RE
Schedlowski M
Source :
European journal of applied physiology and occupational physiology [Eur J Appl Physiol Occup Physiol] 1998 May; Vol. 77 (6), pp. 523-6.
Publication Year :
1998

Abstract

We investigated the mechanisms of stress-induced alterations in adrenocorticotrophin (ACTH) release. Tandem parachutists received either a placebo or the beta-adrenoceptor antagonist propranolol prior to a first time parachute jump. Blood samples were drawn 4 h before, immediately after, and 1 h after the jump. Cortisol and catecholamine concentrations displayed a significant stress-induced increase in both groups. The ACTH plasma concentrations significantly increased in the placebo and the propranolol group, with significantly more pronounced changes in the propranolol-treated subjects compared to the placebo group. These data demonstrated a stress-induced increase of ACTH plasma concentrations in humans that was enhanced by beta-blockade.

Details

Language :
English
ISSN :
0301-5548
Volume :
77
Issue :
6
Database :
MEDLINE
Journal :
European journal of applied physiology and occupational physiology
Publication Type :
Academic Journal
Accession number :
9650737
Full Text :
https://doi.org/10.1007/s004210050370