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Effect of transforming growth factor-beta1 on interleukin-6 secretion in human myoblasts.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 1998 Jul 01; Vol. 87 (1-2), pp. 185-8. - Publication Year :
- 1998
-
Abstract
- Transforming growth factor-beta (TGF-beta) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1beta (IL-1beta) or tumor necrosis factor alpha. In the present report, we show that TGF-beta1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF-beta1 increases IL-1beta effect, while a longer incubation inhibits its action.
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 87
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 9670861
- Full Text :
- https://doi.org/10.1016/s0165-5728(98)00110-6