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Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats.
- Source :
-
The American journal of physiology [Am J Physiol] 1998 Jul; Vol. 275 (1), pp. R180-5. - Publication Year :
- 1998
-
Abstract
- The potent hypophagic effect of OB protein (OB) is well established, but the mechanism of this effect is largely unknown. We investigated the effects of chronic administration of a novel modified recombinant human OB (Mod-OB) with a prolonged half-life (>48 h) on ad libitum food intake, spontaneous meal patterns, and body weight in 24 adult, male Sprague-Dawley rats (body weight at study onset: 292 g). Single daily subcutaneous injections of Mod-OB (4 mg/kg daily) for 8 consecutive days significantly reduced ad libitum food intake compared with vehicle injections from injection day 3 through postinjection day 3. Mod-OB-injected rats ate between 4.5 and 7.1 g (or 13-20%) per day less than controls, with the reduction primarily occurring during the dark period. Body weight gain was significantly decreased in response to Mod-OB from injection day 8 until postinjection day 4, with a maximum difference of 24 g on postinjection day 3. The reduction of food intake by Mod-OB was mainly due to a 21-34% decrease in nocturnal spontaneous meal size. There was no significant effect of Mod-OB on nocturnal meal frequency or duration. Mod-OB also did not reliably affect the size, duration, or frequency of diurnal meals. Mod-OB-injected rats displayed no compensatory hyperphagia after the injection period. These results indicate that chronically administered OB selectively affects the mechanisms controlling meal size in male rats.
- Subjects :
- Animals
Appetite physiology
Body Weight drug effects
Drug Administration Schedule
Humans
Injections, Subcutaneous
Leptin
Male
Obesity
Proteins administration & dosage
Rats
Rats, Sprague-Dawley
Recombinant Proteins administration & dosage
Recombinant Proteins pharmacology
Time Factors
Appetite drug effects
Energy Intake drug effects
Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 275
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 9688977
- Full Text :
- https://doi.org/10.1152/ajpregu.1998.275.1.R180