Back to Search
Start Over
Recombinant human megakaryocyte growth and development factor increases levels of circulating haemopoietic progenitor cells post chemotherapy in patients with acute myeloid leukaemia.
- Source :
-
British journal of haematology [Br J Haematol] 1998 Jul; Vol. 102 (2), pp. 535-43. - Publication Year :
- 1998
-
Abstract
- By participating in a randomized safety and efficacy study of pegylated-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) post induction and consolidation chemotherapy for de novo acute myeloid leukaemia, serial determinations of circulating haemopoietic progenitor cells were performed during 18 chemotherapy courses in eight patients (three receiving placebo; one, 2.5; and four, 5.0 microg/kg/d MGDF, respectively). Whereas failure to achieve complete remission (CR) was generally associated with poor progenitor cell increments following chemotherapy, substantial progenitor cell mobilization consistently occurred during haemopoietic recovery in patients entering, or in CR, with significantly higher peak values in patients receiving 5 microg/kg/d of MGDF as compared to controls. The median increases of progenitor cell numbers by chemotherapy alone and chemotherapy plus 5.0 microg/kg/d MGDF over that in normal individuals with steady-state haemopoiesis were 10- and 45-fold for CFU-GM, 3- and 17-fold for BFU-E, and 2- and 18-fold for CFU-mix. CFU-Mk levels were not increased above normal by chemotherapy alone but were 15-fold enhanced by chemotherapy plus MGDF. Recruitment of CD34+ cells post chemotherapy was also potentiated by MGDF. Our results suggest MGDF as a potent agent to augment progenitor cell mobilization after successful induction or consolidation chemotherapy in patients with AML.
- Subjects :
- Acute Disease
Adult
Aged
Double-Blind Method
Erythropoiesis drug effects
Female
Hematopoiesis drug effects
Humans
Leukocyte Count
Male
Middle Aged
Platelet Count
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Hematopoietic Stem Cell Mobilization methods
Hematopoietic Stem Cells drug effects
Leukemia, Myeloid drug therapy
Thrombopoietin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 102
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 9695971
- Full Text :
- https://doi.org/10.1046/j.1365-2141.1998.00789.x