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Modulated serum activities and concentrations of paraoxonase in high density lipoprotein deficiency states.

Authors :
James RW
Blatter Garin MC
Calabresi L
Miccoli R
von Eckardstein A
Tilly-Kiesi M
Taskinen MR
Assmann G
Franceschini G
Source :
Atherosclerosis [Atherosclerosis] 1998 Jul; Vol. 139 (1), pp. 77-82.
Publication Year :
1998

Abstract

Paraoxonase is a high density lipoprotein (HDL) associated enzyme with a hypothesised role in the protection of low density lipoproteins (LDL) from oxidative stress. The present study examined paraoxonase in several genetically distinct HDL deficiency states. Despite reduction or even absence of detectable HDL, enzyme activity was present in sera from A-I-Pisa, A-I-Helsinki, A-I-Milano and Tangier patients. Both enzyme activities and peptide concentrations were modulated (reduced) but specific activities were broadly similar to controls, suggesting an impact on peptide concentration rather than an inhibition of enzyme activity. Despite the absence of HDL in A-I-Pisa and Tangier subjects, there was no association of paraoxonase with very low density lipoproteins or LDL. Paraoxonase function is maintained in HDL deficient states. It implies that certain HDL-associated anti-atherogenic processes may not be entirely compromised by HDL deficiency. This has important implications for the cardiovascular risk associated with modulated HDL concentrations.

Details

Language :
English
ISSN :
0021-9150
Volume :
139
Issue :
1
Database :
MEDLINE
Journal :
Atherosclerosis
Publication Type :
Academic Journal
Accession number :
9699894
Full Text :
https://doi.org/10.1016/s0021-9150(98)00058-6