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Effects of chronic systemic administration of opioid peptides, naloxone and N-acetyl beta-endorphin antiserum on gonadotropins and testicular functions in the rat.
- Source :
-
Indian journal of experimental biology [Indian J Exp Biol] 1998 Apr; Vol. 36 (4), pp. 361-6. - Publication Year :
- 1998
-
Abstract
- Systemic administration of opioid peptides, methionine-enkephalin and beta-endorphin, chronically, lowered gonadotropin levels in plasma and had an inhibitory effect mainly on the testicular enzymes hyaluronidase, acid phosphatase and on incorporation of 3[H] thymidine in the tissue. When rats were similarly treated with opioid peptide antagonist naloxone and N-acetyl beta-endorphin antiserum, induced an opposite effect. This is either the direct effect of opioid peptides/antagonist on the gonads or it may be via the circulating levels of gonadotropin.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Male
Naloxone pharmacology
Opioid Peptides pharmacology
Rats
Rats, Wistar
Testis physiology
beta-Endorphin administration & dosage
beta-Endorphin pharmacology
Naloxone administration & dosage
Opioid Peptides administration & dosage
Testis drug effects
beta-Endorphin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0019-5189
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Indian journal of experimental biology
- Publication Type :
- Academic Journal
- Accession number :
- 9717445